Research cafe
Machine learning and artificial intelligence in biomedical research
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System biological approachs in genetics and therapeutics of Alzheimer Disease
- The Alzheimer disease (AD) is an age-related neurological disorder of humans characterized by gradual loss of memory and cognitive skills. It accounts for more than 50% of all dementia cases and prevalence among more than 24 million people worldwide. Its moiety is so brutal that over 5 million new cases of AD are reported each year. This disease is divided into 2 subtypes based on the age of onset (i,e) early-onset AD (EOAD) and late-onset AD (LOAD). EOAD accounts for approximately 1% to 6% of all cases among the age group 30 to 65 years. Similarly, LOAD seems to be the most common form of AD which onsets among the age group of more than 60 or 65 years. The genetics of AD has some limitation with three genes (APP, PSEN1, and PSEN2 ) being associated with EOAD and only one gene APOE associated with LOAD onset. we look into some probable candidate genes involved in two subtypes of human Alzheimer disease using the concepts of network biology, molecular modelling and molecular dynamics simulations underlying genetics and therapeutics
Bio-molecular structure and dynamics and way forward
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Computational approches in small molecule drug discovery and designing
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