BIOPRUDENCE RESEARCH INNOVATIONS LLP

Name & Designation

Dr Pabitra Mohan Behera (Application Scientist)

Institute of Computational Biology and Bioinformatics

BIOPRUDENCE RESEARCH INNOVATIONS LLP

Plot No. 639/1053, Laxmi Vihar, Tankapani Road

Bhubaneswar, Odisha, Pin-751002

E-mail: pabitra@icbb-res.org, pabitramohan.rd@gmail.com

Mobile: +91-9776503664, +91-9439770247

Google Scholar: https://scholar.google.co.in/citations?user=zeSE6o4AAAAJ&hl=en

ResearchGate: https://www.researchgate.net/profile/Pabitra_Behera

ORCiD: https://orcid.org/0000-0001-8188-6111

Educational Qualifications

• PhD. Biotechnology from Siksha O Anusandhan University, Bhubaneswar, Odisha in December 2015.   
• MSc Bioinformatics from Odisha University of Agriculture and Technology, Bhubaneswar in November 2006.
• BSc Botany (Hons) & distinction from Utkal University, Odisha, Bhubaneswar in April 2004.
• +2 Science from Council of Higher Secondary Education, Odisha, Bhubaneswar in March 1999.
• H.S.C from Board of Secondary Education, Odisha, Cuttack in April 1997.

Research Experiences (12 years) 

• Working as Application Scientist (Bioinformatics), at Institute of Computational Biology and Bioinformatics, Bhubaneswar from March 2019 to till date.
• Worked as Post-Doctoral Fellow (Institutional), at Institute of Life Science, Bhubaneswar from April 2018 to February 2019.
• Worked as National Post-Doctoral Fellow (N-PDF), DST-SERB at Institute of Life Science, Bhubaneswar from March 2016 to March 2018.
• Worked as a PhD Scholar at Centre of Biotechnology, SOA University, Bhubaneswar from April 2010 to March 2015.

Teaching Experiences (6 years) 

• Teaching Advanced Bioinformatics for Pre-Ph.D course work at Utkal University for 2012-13, 2013-2014 and 2014-2015.
• Teaching Bioinformatics for Pre-Ph.D., M.Sc. and M.Tech. Biotechnology students at Centre of Biotechnology of Siksha O Anusandhan University from 2010 to 2015.   

Post-Doctoral research projects

• Bioinformatics prediction and validation of novel candidate genes in diabetes mellitus
• In this project we extant an integrated bioinformatics analysis featuring genetic information from web resources, GeneOntology enrichment analysis and protein-protein interaction networks. A global protein-protein interaction network was made using medium-confidence interactions of HIPPIE database. Then this confidence scored and functionally annotated interactions were used for fetching of candidate genes described in three sets such as 171 type II diabetes genes reported in DisGeNet (set1), 409 genes associated with highly enriched GO terms (set2) and 1686 genes as hubs in the global network (set3). We propose about 64 candidate genes are closely associated with type II diabetes from which 37 genes were validated through their associations with the SNPs reported for diabetes and their functional enrichment analysis in the STRING database. 
• Computational biology of protein kinases
• Protein kinases are a group of enzymes which play a significant role in every aspect of cellular metabolism. The kinases as mediators of protein phosphorylation are very important in disease pathophysiology (e.g. cancer) using mutational activation or by helping the neoplastic growth. They are considered one of the most important classes of drug targets and design and development of specific kinase inhibitors has, therefore, became a major strategy in drug discovery programs. The ATP binding site has been the established target for kinase inhibitor design. However, the problem of inhibitor selectivity at the highly conserved ATP site has led the kinase inhibitor research towards the identification of allosteric inhibitors. In the published book chapter we have discussed the structure of the kinase domain and the types of inhibitors focusing on allosteric inhibitors.
• The HNSCCDB database: a comprehensive database on head and neck squamous cell carcinoma
• HNSCC DB contains a variety of information such as transcriptomics, sequence and structure related to genes implicated in HNSCC. The database contains hundreds of modelled structures of the proteins for which there is no structural information is available. This fact makes the database unique and highly useful for those who are working in drug design and related projects. It provides a useful tool enabling the structure-based design of modulators of those proteins. Moreover, we have assimilated information from various sources including inhibitors (with IC50/ED50) etc.

Membership of National/ International bodies

• Life member of Proteomics Society India (PSI) (426/2017)
• Life member of Society of Biological Chemists, India SBC (I) (3492/2014)
• Life member of Odisha Bigyan Academy (OBA) (LM-560)
• Life member of Association of Microbiologists of India (AMI/LM-393/2012)
• Life member of The Indian Science Congress Association (ISCA) (L19091)

Publications

Journals

• B. Shankar Panda,   B. Samanta,   S. S. S. S. Sudha Ambadipudi,   S. Nayak,   V. Lakshma Nayak,   S. Ramakrishna,   S. Mohapatra,   P. Mohan Behera,   L. Samanta, ChemistrySelect 2024,  9, e202400115. (Impact Factor: 3.600) https://doi.org/10.1002/slct.202400115
• Singh R, Kumar R, Roy A, Behera PM, Atri AK, Kumar K, Manna D, Dixit A,  Patil MT, Mankamna Kumari R, Nimesh S, Salunke DB.  Imidazo[2,1-b]thiazole based indoleamine-2,3-dioxygenase 1 (IDO1)  inhibitor: Structure based design, synthesis, bio-evaluation and docking  studies. Bioorg Med Chem Lett. 2023, 96:129532.  (Impact Factor: 2.700) (PMID: 37866714). https://doi.org/10.1016/j.bmcl.2023.129532
• Biswal, P. K., Behera, S., Mohapatra, S., Sharma, T., Kar, D. M., Samanta, L., Behera, P. M., Kar, R. K., Computational prediction of gamma-oryzanol as potential agonist of human peroxisome proliferator-activated receptor gamma (ppar-γ), bioRxiv, 2023, 542647, 1-24.
• Tanty, D K., Sahu, P. R., Behera, S., Mohapatra, R., Behera, P. M., Sahu, S. K., Computational identification validation and structural characterisation of some potential candidate genes for diabetes mellitus, bioRxiv, 2022, 505395, 1-30.
• Behera, P. M., Kumar, R., Dixit, A., Integrated bioinformatics analysis and assessment of some important candidate genes for type II diabetes. (Manuscript submitted to PLOS Computational Biology) 
• Satpathy, S., Behera, P. M., Tanty, D. K., Srivastava, S., Thatoi, H. N., Dixit, A., Sahoo, S. L., Isolation and molecular identification of pectinase producing Aspergillus species from different soil samples of Bhubaneswar regions, BioRxiv (https://doi.org/10.1101/837112).
• Sharma, N., Dabas, P., Dhingra, Y., Sweta,  K., Chakrabarty,  M., Singhal, R., Tyagi, P., Behera, P. M., Dixit, A., Bhattacharjee, S., Arabidopsis thaliana possesses two novel ELL Associated Factor (EAF) Homologs, IUBMB Life. 2021, 1-16. (Impact Factor: 3.885)
• Koochana, P. K., Mohanty, A., Parida, A., Behera, Narmada., Behera, P. M., Dixit, A., Behera, R., Flavin mediated Reductive Iron Mobilization from Frog M and Mycobacterial Ferritins: Impact of their Size, Charge and Reactivities with NADH/O2. Journal of Biological Inorganic Chemistry, 2021, 1-17. (Impact Factor: 3.358) (PMID: 33598740) 
• Behera, D. K., Behera, P. M., Acharya, L., Dixit, A., Pharmacophore modelling, virtual screening and molecular docking studies on PLD1 inhibitors, SAR and QSAR in Environmental Research, 28, (2017), 991-1009. (Impact Factor: 3.000)
• Behera, D. K., Behera, P. M., Acharya, L., Dixit, A., Development and validation of pharmacophore and QSAR models for influenza PB2 inhibitors, Chemical Biology Letters, 4(1), (2017), 1-8. (Impact Factor: 4.400) 
• Behera, P. M., Behera, D. K., Satpati, S., Agnihotri, G., Nayak, S., Padhi, P., Dixit, A., Molecular modelling and identification of novel glucokinase activators through stepwise virtual screening, Journal of Molecular Graphics and Modelling, 57, (2015), 122–130. (Impact Factor: 2.518)
• Behera, P. M., Behera, D. K., Panda, A., Dixit, A., Padhi, P., In silico Expressed Sequence Tag (EST) analysis in the identification of novel diabetic genes as virtual therapeutic targets, BioMed Research International, Volume 2013, Article ID 704818, 9 pages, DOI: 10.1155/2013/704818. (Impact Factor: 3.411) PMID: 23509765
• Behera, D. K., Behera, P. M., Dixit, A., Acharya, L., Padhi, P., In silico biology of H1N1: molecular modelling of novel receptors and docking studies of inhibitors to reveal new insight in flu treatment, Journal of Biomedicine and Biotechnology, Volume 2012, Article ID 714623, 7 pages,doi:10.1155/2012/714623. (Impact Factor: 3.411) PMID: 23125526
• Behera, P. M., Sethi, B. K., Behera, K. K., Pani, D., Sahoo, S. L., Padhy, S., Computational Analysis of POL Gene of Human Immunodeficiency Virus Type 1 (HIV-1), Not. Bot. Hort. Agro.  Cluj-Napoca Vol. 37, No 2 (2009), 264-269. (Impact Factor: 1.444) 

Books Chapter

• Behera, P. M., Dixit, A., The story of kinase inhibitors development with special reference to the allosteric site, A. Grover (ed.) Drug Design: Principles and Applications, Springer Nature Singapore Pte. Ltd. 2017, 57-68, ISBN: 978-981-10-5186-9. (DOI 10.1007/978-981-10-5187-6_5) 

Seminar/ Conference abstracts/papers

• Behera, P. M., Kumar, R., Dixit, A., Prediction and validation of potential candidate genes for type II diabetes mellitus using bioinformatics analysis. Souvenir of 9th International Symposium of Computational Methods in Toxicology and Pharmacology Integrating Internet Resources. (2017): p. 65.
• Behera, P. M., Satpati, S., Behera, D.K., Dixit, A., Molecular modelling and dynamics studies of toll-like receptor-8 (TLR-8). Compendium of Symposium on Accelerating Biology 2017: Delivering precision, (2017): p. 118-119.
• Behera, P. M., Behera, D.K., Nayak, S., Padhi, P., Dixit, A., Identification of human Glucokinase agonists using structure-based drug design. Souvenir of 6th International Symposium on Current Trends in Drug Discovery Research, (2016): p. 88.
• Behera, P. M., Behera, D.K., Samantaray, S., Nayak, S., Padhi, P., In silico analysis of ICA1 gene to explore its credentials in diabetic research. Souvenir of 83rd Annual Meeting of Society of Biological Chemists (India), (2014): P-18-06:p.3.
• Behera, P. M., Behera, D.K., Nayak, S., Padhi, P., Dixit, A., Molecular modelling and identification of glucokinase activators through molecule docking and molecular dynamics simulations. Souvenir of First International Conference on Recent Advances in Computational Drug Design, (2013), RACDD-419.
• Behera, P. M., Behera, D.K., Panda, A., Dixit, A., Padhi, P., Molecular modelling of high-quality EST sequences and structure-based virtual screening in the identification of novel anti-diabetic entities. Souvenir of International conference on Biotechnology Advances: Omics approaches and way forward (ICBA-2012), (2012):p.38.
• Behera, P. M., Dixit, A., Nayak, S., Padhi, P., In silico Expressed Sequence Tag (EST) analysis in the identification of novel diabetic genes as virtual therapeutic targets, Souvenir of 3rd International Conference on Bioinformatics and Systems Biology (INCOBS-2012), (2012): p-70-71.
• Behera, P. M., Panda, A., Sethi, B. K., Nayak, S., Padhi, P., Docking and QSAR studies of PTP1B inhibitors: an in silico approach in potential drug designing. Souvenir of Recent Advances in Bioinformatics, (2010): p. 85-88. 
• Behera, P. M., Panda, A., Nayak, S., Padhi, P., Molecular Modeling and Structural characterization of BRCA1-ZBRK1 complex to interpret novel insights in cancer biology, Souvenir of 4th International Symposium on Current Trends in Drug Discovery Research, (2010): p. 88.

Seminars/Conferences/workshop  attended 

• Attended 40th annual conference of Indian Association for Cancer Research (virtual mode) on 1st March 2021 at Institute of Life Sciences, Bhubaneswar, Odisha, India.
• Attended the webinar on DBT’s response to COVID-19 (virtual mode) organized by Department of Biotechnology (DBT) in association with DBT/Wellcome Trust India Alliance on 3rd July 2020.
• Attended the National Seminar on “Future India: Science and Technology” on the occasion of Indian Science Congress Association Bhubaneswar Chapter 2019, December 1-2, 2019 at KIIT University, Bhubaneswar, Odisha, India. 
• Attended the DBT sponsored short term training programme on “BASIC TOOLS AND TECHNIQUES IN CELL BIOLOGY AND IMMUNOLOGY” from 26th August to 14th September 2019 at KIIT University, Bhubaneswar, Odisha, India. 
• Attended the National symposium on “Emerging Trends in Biological Sciences Research” March 18-19, 2019 at Institute of Life Sciences, Bhubaneswar, Odisha, India. 
• Attended the National Seminar on “Science for Society” on the occasion of 20th Odisha Bigyan ‘O’ Paribesh Congress 2018, November 17-18, 2018 at National Institute of Science Education and Research, Bhubaneswar, Odisha, India.
• Attended the 9th International Symposium on Computational Methods in Toxicology and Pharmacology Integrating Internet Resources (CMTPI-2017), October 27-30, 2017 at Bogmallo Beach Resorts, Bogmallo, Goa, India.
• Attended the International Conference on NextGen Genomics, Biology, Bioinformatics and Technologies (NGBT-2017), October 02-04, 2017 at Hotel Mayfair Lagoon, Bhubaneswar, Odisha, India.
• Attended the National symposium and workshop on quantitative proteomics, March 06-10, 2017 at Institute of Life Sciences, Bhubaneswar, Odisha, India.
• Attended the National symposium on “Accelerating Biology 2017: Delivering precision”, January 17-19, 2017 at C-DAC, Pune, Maharashtra, India. 
• Attended the One-day workshop on “Next Generation Sequencing Data Analysis” organized by India-United Kingdom Bioinformatics Network, 16th January 2017 at C-DAC, Pune, Maharashtra, India.
• Attended the 2nd meeting of Indian Immunological Society Odisha Chapter, 6th January 2017 at NISER, Bhubaneswar, Odisha, India.  
• Attended the National Seminar on “Science and Technology for National Development in India” on the occasion of Indian Science Congress Association Bhubaneswar Chapter 2016, December 12-13, 2016 at KIIT University, Bhubaneswar, Odisha, India. 
• Attended the 6th International Symposium on “Current Trends in Drug Discovery Research” February 25-28, 2016 at Central Drug Research Institute, Lucknow, Uttar Pradesh, India. 
• Attended the National Seminar on “Science and Technology for Indigenous Development in India” on the occasion of Indian Science Congress Association Bhubaneswar Chapter 2015, December 09-11, 2015 at KIIT University, Bhubaneswar, Odisha, India. 
• Attended the Symposium on “Evolution: Molecules to Life” on the occasion of 83rd Annual Meeting of Society of Biological Chemists (India), December 18-21, 2014 at KIIT University, Bhubaneswar, Odisha, India. 
• Attended the Workshop on Quantitative Biology on the occasion of 83rd Annual Meeting of Society of Biological Chemists (India), 17th December 2014 at Institute of Life Sciences, Bhubaneswar, Odisha, India.
• Attended the National Seminar on “Science & Technology for Human Development” on the occasion of 17th Odisha Bigyan Congress 2014, December 5-6, 2014 at Institute of Technical Education and Research, Siksha O Anusandhan University, Bhubaneswar, Odisha, India.
• Attended the National seminar on Oxidative stress: disorders and management, October 24-25, 2014 at School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar, Odisha, India.
• Attended the International Workshop on Structural Biology and its application to Parasitic Diseases, March 3-7, 2014 at National Centre for Cell Science, Pune, Maharashtra, India.
• Attended the National Seminar on “Innovations in Science & Technology for Inclusive Development” on the occasion of 16th Odisha Bigyan Congress 2013, November 23-24, 2013 at Institute of Physics, Bhubaneswar, Odisha, India.
• Attended the First International Conference on “Recent Advances in Computational Drug Design”, September 16-17, 2013 at Indian Institute of Science, Bangalore, Karnataka, India. 
• Attended the National Workshop on Drug Design and Discovery, February 18-21, 2013 at Institute of Life Sciences, Bhubaneswar, Odisha, India.
• Attended the 100th session of Indian Science Congress 2013, January 3-7, 2013 at University of Calcutta, Kolkata, West Bengal, India.
• Attended the International Conference on Biotechnology Advances: Omics approaches and way forward (ICBA-2012), December 20-22, 2012 at Siksha O Anusandhan University, Bhubaneswar, Odisha, India.
• Attended the National Conference on “Science for shaping the future of India” on the occasion of 15th Odisha Bigyan Congress 2012, October 18-19, 2012 at Utkal University, Bhubaneswar, Odisha, India.
• Attended the complimentary seminar on MATLAB and Simulink for engineering students, September, 21st 2012 at Hotel Swasti Premium, Bhubaneswar, Odisha, India.
• Attended the 3rd International Conference on Bioinformatics and Systems Biology (INCOBS-2012), February 16-18, 2012 at Annamalai University, Annamalai Nagar, Tamil Nadu, India.    
• Attended the 99th Indian Science Congress 2012, January 3-7, 2012 at KIIT University, Bhubaneswar, Odisha, India.
• Attended the International Conference on “Recent Advances in Bioinformatics” September 3-5, 2010 at KIIT University, Bhubaneswar, Odisha, India. 
• Attended the 4th International Symposium on “Current Trends in Drug Discovery Research” February 17-21, 2010 at Central Drug Research Institute, Lucknow, Uttar Pradesh, India. 
• Attended the National Seminar on “Industrially important microorganisms and their biosafety” March 27, 2009, at Utkal University, Bhubaneswar, Odisha, India.
• Attended the 3rd International Symposium on “Current Trends in Drug Discovery Research” February 17-21, 2007 at Central Drug Research Institute, Lucknow, Uttar Pradesh, India. 
• Attended the National Seminar on “Frontier Bioinformatics Tools in the genome and proteome Analysis” March 14-15, 2005 at Odisha University of Agriculture and Technology, Bhubaneswar, Odisha, India.

Achievements

• Involved in guidance of 5 MPharm students of Dadhichi College of Pharmacy, Cuttack, Odisha for their 6 month dissertation work at Institute of Computational Biology and Bioinformatics from January 2021 to June 2021.  
• Involved in guidance of 2 Integrated MSc Bioinformatics students of BJB Autonous College, Bhubaneswar, Odisha for their 6 month dissertation work at Institute of Computational Biology and Bioinformatics from January 2020 to June 2020.  
• Presented a poster entitled “Prediction and validation of potential candidate genes for diabetes mellitus using bioinformatics analysis” in 9th International Symposium on Computational Methods in Toxicology and Pharmacology Integrating Internet Resources (CMTPI-2017), October 27-30, 2017 at Bogmallo Beach Resorts, Bogmallo, Goa, India. 
• Presented a poster entitled “Prediction and validation of potential candidate genes for diabetes mellitus using bioinformatics analysis” in International conference on NextGen Genomics, Biology, Bioinformatics and Technologies (NGBT-2017) at Hotel Mayfair Lagoon, Bhubaneswar, Odisha, India. 
• Presented a poster entitled “Molecular modelling and dynamics studies of toll-like receptor-8 (TLR-8)” in National symposium on Accelerating Biology 2017: Delivering precision, at C-DAC, Pune, Maharashtra, India. 
• Presented a poster entitled “Identification of human Glucokinase agonists using structure-based drug design” in 6th International Symposium on Current Trends in Drug Discovery Research (CTDDR-2016) at Central Drug Research Institute, Lucknow, Uttar Pradesh, India.
• Presented a poster entitled “In silico analysis of ICA1 gene to explore its credentials in diabetic research” in 83rd Annual meeting of SBC (I) and Symposium on Evolution: Molecules to Life” at KIIT University, Bhubaneswar, Odisha, India.
• Presented a poster entitled “In silico docking studies of Curcumin on selective drug targets for Alzheimer’s disease” in Innovations in Science & Technology for Inclusive Development on the occasion of 16th Odisha Bigyan Congress 2013, at Institute of Physics, Bhubaneswar, Odisha, India. (Awarded for best poster)
• Presented a poster entitled “Molecular modelling and identification of glucokinase activators through molecule docking and molecular dynamics simulations” in First International Conference on Recent Advances in Computational Drug Design (RACDD 2013) at Indian Institute of Science, Bangalore, Karnataka, India.
• Delivered an oral presentation on “Molecular modelling of high-quality EST sequences and structure-based virtual screening in the identification of novel anti-diabetic entities” in International conference on Biotechnology Advances: Omics approaches and way forward (ICBA-2012) at Siksha O Anusandhan University, Bhubaneswar, Odisha, India., Bhubaneswar, Odisha, India.
• Presented a poster entitled “In silico expressed sequence tag (EST) analysis in the identification of novel diabetic genes as virtual therapeutic targets” in 3rd International Conference on Bioinformatics and Systems Biology (INCOBS-2012) at Annamalai University, Annamalai Nagar, Tamil Nadu, India. (Awarded for best poster) 
• Involved in guidance of 10 MSc Biotechnology students of Centre of Biotechnology, Siksha O Anusandhan University for their 6-month dissertation work at Research and Development Centre, Hi-Tech Medical College and Hospital from January 2011 to July 2011.  
• Presented a poster entitled “Docking and QSAR studies of PTP1B inhibitors: an in silico approach in potential drug designing” in International Conference on Recent Advances in Bioinformatics at KIIT University, Bhubaneswar, Odisha, India.
• Presented a poster entitled “Molecular Modeling and Structural characterization of BRCA1-ZBRK1 complex to interpret novel insight in cancer biology” in 4th International Symposium on Current Trends in Drug Discovery Research (CTDDR-2010) at Central Drug Research Institute, Lucknow, Uttar Pradesh, India.
• Delivered an oral presentation on “Insight to Bioinformatics in Microbiology” in National seminar on “Industrially important microorganisms and their biosafety” at Utkal University, Bhubaneswar, Odisha, India.
• Owns the authorship for sequences FM992375, FM992376, FM994156 submitted to EMBL.